PCN104 The Appropriate Health Economic Modeling Approach in Cancer Screening Tests

Different health economic (HE) models are used to simulate real-world practice. The choice of model depends on the disease arearesearch question, and objectives. In cancer screening tests, two common issues that risk changes dramatically over patient’s lifetime protocols usually a combination tests (eg, initial follow-up testing). There limitations properly addressing these in HE models. present study aims investigate which type can appropriately practice ovarian cancer, colorectal (CRC), prostate cancer. A targeted search studies was conducted for CRC, modeling data from manuscripts published between 2015 2021 were extracted, benefits different types evaluated. Forty-six met inclusion criteria. Partitioned survival (PSMs) not any included studies. Model decision tree (4.3%), Markov (56.5%), microsimulation (39.1%). Microsimulation models, including discrete event simulation, commonly modelling CRC but Decision useful when problem involves continuous level time, tumor varies cannot capture this effect since they consider constant malignancy all individuals. PSM has limitation conditions with multiple states; consequently, none method. effectively time; moreover, precisely interaction multimodal methods.